论文发表

代表性研究论文

  1. Jia, H., Y. Guo, X. Song, C. Shao, J. Wu, J. Ma, M. Shi, Y. Miao, R. Li, D. Wang, Z. Tian, and W. Xiao. 2016. Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-alpha/Fc fusion proteins expressed in Pichia pastoris. Microb Cell Fact 15: 209.

  2. Sun, H., J. Song, C. Weng, J. Xu, M. Huang, Q. Huang, R. Sun, W. Xiao, and C. Sun. 2016. Decreased expression of the macrophage scavenger receptor MARCO is associated with tumour progression and poor prognosis in human hepatocellular carcinoma. Journal of gastroenterology and hepatology.

  3. Sun, H., J. Xu, M. Huang, Q. Huang, R. Sun, W. Xiao, and C. Sun. 2016. CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma. Immunology letters 178: 105-113.

  4. Zhou, Y., F. Xu, F. Tao, D. Q. Feng, B. Ling, L. L. Qian, X. Yang, Q. Y. Wang, H. Y. Wang, W. D. Zhao, Y. Cheng, G. Shan, D. V. Kalvakolanu, and W. H. Xiao. 2016. GRIM-19 Restores Cervical Cancer Cell Senescence by Repressing hTERT Transcription. J. Interferon Cytokine Res. 36: 506-515.

  5. Yang, L., R. Li, S. X. Xiang, and W. H. Xiao. 2016. MafB, a Target of MicroRNA-155, Regulates Dendritic Cell Maturation. Open Life Sci. 11: 46-54.

  6. Wang, D., J. Y. Chen, R. Li, G. L. Wu, Z. M. Sun, Z. T. Wang, Z. M. Zhai, F. Fang, Y. G. Guo, Y. J. Zhong, M. Jiang, H. Xu, M. H. Chen, G. D. Shen, J. Sun, B. L. Yan, C. D. Yu, Z. G. Tian, and W. H. Xiao. 2016. PAX5 interacts with RIP2 to promote NF-kappa B activation and drug-resistance in B-lymphoproliferative disorders. J. Cell Sci. 129: 2261-2272.

  7. Gao, B., J. Xu, K. W. He, L. Shen, H. Chen, H. J. Yang, A. H. Li, and W. H. Xiao. 2016. Cellular Uptake and Intra-Organ Biodistribution of Functionalized Silica-Coated Gold Nanorods. Mol. Imaging. Biol. 18: 667-676.

  8. Wang, Z. T., L. L. Zhang, H. P. Wang, S. D. Xiong, Y. L. Li, Q. S. Tao, W. H. Xiao, H. Qin, Y. P. Wang, and Z. M. Zhai. 2015. Tumor-induced CD14(+)HLA-DR-/low myeloid-derived suppressor cells correlate with tumor progression and outcome of therapy in multiple myeloma patients. Cancer Immunol. Immunother. 64: 389-399.

  9. Sun, C., J. Xu, J. X. Song, C. Q. Liu, J. Y. Wang, C. C. Weng, H. Y. Sun, H. M. Wei, W. H. Xiao, R. Sun, and Z. G. Tian. 2015. The predictive value of centre tumour CD8(+) T cells in patients with hepatocellular carcinoma: comparison with Immunoscore. Oncotarget 6: 35602-35615.

  10. Sun, C., H. Y. Sun, W. H. Xiao, C. Zhang, and Z. G. Tian. 2015. Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy. Acta Pharmacol. Sin. 36: 1191-1199.

  11. Guo, Y. G., J. Wu, H. Jia, W. Chen, C. S. Shao, L. Zhao, J. J. Ma, R. Li, Y. J. Zhong, F. Fang, D. Wang, J. Sun, F. Qian, X. R. Dai, G. H. Zhang, Z. G. Tian, B. X. Li, and W. H. Xiao. 2015. Balancing the Expression and Production of a Heterodimeric Protein: Recombinant Agkisacutacin as a Novel Antithrombotic Drug Candidate. Sci Rep 5: 10.

  12. Gao, B., L. Shen, K. W. He, and W. H. Xiao. 2015. GNRs@SiO2-FA in combination with radiotherapy induces the apoptosis of HepG2 cells by modulating the expression of apoptosis-related proteins. Int. J. Mol. Med. 36: 1282-1290.

  13. Zhou, Y., F. Tao, Y. Cheng, F. Xu, F. Q. Yao, D. Q. Feng, L. Miao, W. H. Xiao, and B. Ling. 2014. Up-regulation of ITCH is associated with down-regulation of LATS1 during tumorigenesis and progression of cervical squamous cell carcinoma. Clin. Invest. Med. 37: E384-E394.

  14. Zhong, Y. J., L. Yang, Y. G. Guo, F. Fang, D. Wang, R. Li, M. Jiang, W. Y. Kang, J. J. Ma, J. Sun, and W. H. Xiao. 2014. High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10. Microb. Cell. Fact. 13: 10.

  15. Wu, H. M., Z. F. Jiang, X. Y. Fan, T. Wang, X. Ke, X. B. Yan, Y. Ma, W. H. Xiao, and R. Y. Liu. 2014. Reversed expression of GRIM-1 and GRP78 in human non small cell Lung cancer. Hum. Pathol. 45: 1936-1943.

  16. Sun, H. Y., C. Sun, and W. H. Xiao. 2014. Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations. Cytokine 65: 33-41.

  17. Ren, Z. J., W. Y. Kang, L. H. Wang, B. L. Sun, J. J. Ma, C. G. Zheng, J. Sun, Z. G. Tian, X. Y. Yang, and W. H. Xiao. 2014. E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-kB modulation. Mol. Cancer 13: 13.

  18. Hu, X. L., Y. F. Jiang, X. R. Li, Y. H. Gao, X. L. Guo, X. M. Chi, H. Q. Yan, J. Y. Feng, J. Zhong, B. Sun, X. Shao, W. H. Xiao, Y. Pan, and J. Q. Niu. 2014. Long-Term Effect on Natural Killer Cells by Interferon-alpha Therapy on the Outcomes of HCV Infection. J. Interferon Cytokine Res. 34: 366-375.

  19. Guo, Y. G., R. Li, X. P. Song, Y. J. Zhong, C. G. Wang, H. Jia, L. D. Wu, D. Wang, F. Fang, J. Ma, W. Y. Kang, J. Sun, Z. G. Tian, and W. H. Xiao. 2014. The Expression and Characterization of Functionally Active Soluble CD83 by Pichia pastoris Using High-Density Fermentation. PLoS One 9: 8.

  20. Sun, H. Y., C. Sun, Z. G. Tian, and W. H. Xiao. 2013. NK cells in immunotolerant organs. Cell. Mol. Immunol. 10: 202-212.

  21. Guo, Y. G., G. Luan, G. D. Shen, L. D. Wu, H. Jia, Y. J. Zhong, R. Li, G. W. Li, Y. Shen, J. Sun, S. Y. Hu, and W. H. Xiao. 2013. Production and characterization of recombinant 9 and 15 kDa granulysin by fed-batch fermentation in Pichia pastoris. Appl. Microbiol. Biotechnol. 97: 7669-7677.

  22. Cheng, M., Y. Y. Chen, W. H. Xiao, R. Sun, and Z. G. Tian. 2013. NK cell-based immunotherapy for malignant diseases. Cell. Mol. Immunol. 10: 230-252.

  23. Ma, Y., Q. Q. Cheng, Z. J. Ren, L. Xu, Y. Zhao, J. Sun, S. Y. Hu, and W. H. Xiao. 2012. Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate cancer cells. Cancer Lett. 317: 150-156.

  24. Guo, Y. G., W. Y. Kang, Y. J. Zhong, R. Li, G. W. Li, Y. Shen, S. Y. Hu, J. Sun, and W. H. Xiao. 2012. Purification and characterization of human IL-10/Fc fusion protein expressed in Pichia pastoris. Protein Expr. Purif. 83: 152-156.

  25. Deng, X. W., H. Terunuma, M. Nieda, W. H. Xiao, and A. Nicol. 2012. Synergistic cytotoxicity of ex vivo expanded natural killer cells in combination with monoclonal antibody drugs against cancer cells. Int. Immunopharmacol. 14: 593-605.

  26. Cheng, Y., Y. Zhou, W. J. Jiang, X. Yang, J. Zhu, D. Q. Feng, Y. Wei, M. Li, F. Q. Yao, W. P. Hu, W. H. Xiao, and B. Ling. 2012. Significance of E-cadherin, beta-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma. Hum. Pathol. 43: 1213-1220.

  27. Zhou, Y., Y. Wei, J. Zhu, Q. Y. Wang, L. Bao, Y. Ma, Y. Chen, D. Q. Feng, A. J. Zhang, J. Sun, S. C. Nallar, K. Shen, D. V. Kalvakolanu, W. H. Xiao, and B. Ling. 2011. GRIM-19 Disrupts E6/E6AP Complex to Rescue p53 and Induce Apoptosis in Cervical Cancers. PLoS One 6: 12.

  28. Zhang, X. L., W. H. Xiao, L. H. Wang, Z. G. Tian, and J. Zhang. 2011. Deactivation of Signal Transducer and Activator of Transcription 3 Reverses Chemotherapeutics Resistance of Leukemia Cells via Down-Regulating P-gp. PLoS One 6: 10.

  29. Zhou, Y., Q. Q. Xu, B. Ling, W. H. Xiao, and P. S. Liu. 2011. Reduced expression of Delta Np63 alpha in cervical squamous cell carcinoma. Clin. Invest. Med. 34: E184-E191.

  30. Shen, G. D., H. Huang, A. L. Zhang, T. Zhao, S. Y. Hu, L. S. Cheng, J. Liu, W. H. Xiao, B. Ling, Q. A. Wu, L. H. Song, and W. Wei. 2011. In vivo activity of novel anti-ErbB2 antibody chA21 alone and with Paclitaxel or Trastuzumab in breast and ovarian cancer xenograft models. Cancer Immunol. Immunother. 60: 339-348.

  31. Fang, F., Y. Wang, R. Li, Y. Zhao, Y. Guo, M. Jiang, J. Sun, Y. Ma, Z. J. Ren, Z. G. Tian, F. Wei, D. Yang, and W. H. Xiao. 2010. Transcription Factor E2F1 Suppresses Dendritic Cell Maturation. J. Immunol. 184: 6084-6091.

  32. Hofmann, E. R., S. C. Nallar, L. M. Lin, J. D’Cunha, D. J. Lindner, X. A. Weihua, and D. V. Kalvakolanu. 2010. Identification and characterization of GRIM-1, a cell-death-associated gene product. J. Cell Sci. 123: 2781-2791.

  33. Ma, J. J., Z. J. Ren, Y. Ma, L. Xu, Y. Zhao, C. G. Zheng, Y. H. Fang, T. Xue, B. L. Sun, and W. H. Xiao. 2009. Targeted Knockdown of EGR-1 Inhibits IL-8 Production and IL-8-mediated Invasion of Prostate Cancer Cells through Suppressing EGR-1/NF-kappa B Synergy. J. Biol. Chem. 284: 34600-34606.

  34. Zhou, Y., M. Li, Y. Wei, D. Q. Feng, C. Peng, H. Y. Weng, Y. Ma, L. Bao, S. Nallar, S. Kalakonda, W. H. Xiao, D. V. Kalvakolanu, and B. Ling. 2009. Down-Regulation of GRIM-19 Expression Is Associated With Hyperactivation of STAT3-Induced Gene Expression and Tumor Growth in Human Cervical Cancers. J. Interferon Cytokine Res. 29: 695-703.

  35. Zheng, C. G., Z. J. Ren, H. T. Wang, W. C. Zhang, D. V. Kalvakolanu, Z. G. Tian, and W. H. Xiao. 2009. E2F1 Induces Tumor Cell Survival via Nuclear Factor-kappa B-Dependent Induction of EGR1 Transcription in Prostate Cancer Cells. Cancer Res. 69: 2324-2331.

  36. Li, H., P. Gade, W. Xiao, and D. V. Kalvakolanu. 2007. The interferon signaling network and transcription factor C/EBP-beta. Cell. Mol. Immunol. 4: 407-418.

  37. Zhang, W. C., W. H. Xiao, H. M. Wei, J. Zhang, and Z. G. Tian. 2006. mRNA secondary structure at start AUG codon is a key limiting factor for human protein expression in Escherichia coli. Biochem. Biophys. Res. Commun. 349: 69-78.

  38. Hodge, D. R., W. H. Xiao, B. J. Peng, P. C. Cherry, D. J. Munroe, and W. L. Farrar. 2005. Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis. Cancer Res. 65: 6255-6263.

  39. Xiao, W. H., D. R. Hodge, L. H. Wang, X. Y. Yang, X. H. Zhang, and W. L. Farrar. 2004. Co-operative functions between nuclear factors NF kappa B and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells. Prostate 61: 354-370.

  40. Xiao, W. H., D. R. Hodge, L. H. Wang, X. Y. Yang, X. H. Zhang, and W. L. Farrar. 2004. NF-kappa B activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NF kappa B regulatory site in autocrine human multiple myeloma cells. Cancer Biol. Ther. 3: 1007-1017.

  41. Xiao, W. H. 2004. Advances in NF-kappa B Signaling Transduction and Transcription. Cell. Mol. Immunol. 1: 425-435.

  42. Pengt, B., D. R. Hodge, S. B. Thomas, J. M. Cherry, D. J. Munroe, C. Pompeia, W. H. Xiao, and W. L. Farrar. 2005. Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells. J. Biol. Chem. 280: 4182-4187.

  43. Wang, L. H., X. Y. Yang, X. H. Zhang, J. Q. Huang, J. Hou, J. Li, H. Xiong, K. Mihalic, H. M. Zhu, W. H. Xiao, and W. L. Farrar. 2004. Transcriptional inactivation of STAT3 by PPAR gamma suppresses IL-6-responsive multiple myeloma cells. Immunity 20: 205-218.

  44. Hodge, D. R., W. H. Xiao, L. H. Wang, D. P. Li, and W. L. Farrar. 2004. Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells. Cancer Biol. Ther. 3: 188-194.

  45. Wang, L. H., X. Y. Yang, X. H. Zhang, K. Mihalic, Y. X. Fan, W. H. Xiao, O. M. Z. Howard, E. Appella, A. T. Maynard, and W. L. Farrar. 2004. Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nat. Med. 10: 40-47.

  46. Wang, L. H., X. Y. Yang, X. H. Zhang, K. Mihalic, W. H. Xiao, and W. L. Farrar. 2003. The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity. Cancer Res. 63: 2046-2051.

  47. Yang, X. Y., L. H. Wang, K. Mihalic, W. H. Xiao, T. S. Chen, P. Li, L. M. Wahl, and W. L. Farrar. 2002. Interleukin (IL-4) indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macrophage-derived 12/15-lipoxygenase ligands. J. Biol. Chem. 277: 3973-3978.

  48. Xiao, W. H., L. H. Wang, X. Y. Yang, T. S. Chen, D. Hodge, P. F. Johnson, and W. Farrar. 2001. CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma) gene transcription in human monocytic cells. J. Biol. Chem. 276: 23275-23281.

  49. Xiao, W. H., J. B. Hu, S. K. Roy, S. B. Mannino, and D. V. Kalvakolanu. 2000. Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta (C/EBP-beta). Biochim. Biophys. Acta-Gene Struct. Expression 1492: 163-171.

  50. Roy, S. K., S. J. Wachira, W. H. Xiao, J. B. Hu, and D. V. Kalvakolanu. 2000. CCAAT/enhancer-binding protein-beta regulates interferon-induced transcription through a novel element. J. Biol. Chem. 275: 12626-12632.

  51. Xiao, W. H., L. Wang, and D. V. Kalvakolanu. 1999. Regulation of interferon-alpha/beta-stimulated gene expression through the gamma-activated transcriptional element. Antiviral Res. 40: 145-153.

  52. Held, T. K., W. H. Xiao, Y. Liang, D. V. Kalvakolanu, and A. S. Cross. 1999. Gamma interferon augments macrophage activation by lipopolysaccharide by two distinct mechanisms, at the signal transduction level and via an autocrine mechanism involving tumor necrosis factor alpha and interleukin-1. Infect. Immun. 67: 206-212.

  53. Xiao, W. H., S. Ramanujam, D. J. Lindner, R. D. Kudaravalli, R. Freund, and D. V. Kalvakolanu. 1998. The polyoma virus T antigen interferes with interferon-inducible gene expression. Proc. Natl. Acad. Sci. U. S. A. 95: 1085-1090.

  54. Li, X. L., M. Boyanapalli, W. H. Xiao, D. V. Kalvakolanu, and B. A. Hassel. 1998. Induction of interferon synthesis and activation of interferon-stimulated genes by liposomal transfection reagents. J. Interferon Cytokine Res. 18: 947-952.

  55. Hofman, E. R., M. Boyanapalli, D. J. Lindner, W. H. Xiao, B. A. Hassel, R. Jagus, P. L. Gutierrez, and D. V. Kalvakolanu. 1998. Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid. Mol. Cell. Biol. 18: 6493-6504.

  56. Xiao, W. H., V. Kolla, and D. V. Kalvakolanu. 1997. Interferon gamma-induced transcription of the murine ISGF3 gamma (p48) gene is mediated by novel factors. Proc. Natl. Acad. Sci. U. S. A. 94: 103-108.

  57. Xiao, W. H., D. J. Lindner, and D. V. Kalvakolanu. 1997. The interferon-inducible murine p48 (ISGF3 gamma) gene is regulated by protooncogene c-myc. Proc. Natl. Acad. Sci. U. S. A. 94: 7227-7232.

  58. Xiao, W. H., V. Kolla, and D. V. Kalvakolanu. 1997. Modulation of interferon action by retinoids – Induction of murine STAT1 gene expression by retinoic acid. J. Biol. Chem. 272: 9742-9748.