肖卫华教授简介

肖卫华,教授,博导
医药生物技术系常务副主任;医药生物安徽省工程技术研究中心主任;安徽省生物工程学会理事长。
地址:  安徽省合肥市黄山路443号,230027,中国科学技术大学生命学院
电话:  (0551) 63606294(办公室) ; (0551)63600536(实验室)
电子邮箱:  xiaow@ustc.edu.cn
Web Site:  http://lstt.ustc.edu.cn  http://gmp.ustc.edu.cn

教育与科研经历:
1962年出生于吉林长春。1985年毕业于白求恩医科大学本科,2002年美国约翰·霍普金斯大学硕士,2008吉林大学医学博士。1985-1995年长春生物制品研究所应用分子生物助理研究员,1995年-1998年美国马里兰大学肿瘤研究中心博士后,1998-2004年美国国立肿瘤研究院研究员,2004年10月中国科学技术大学生命科学学院教授,信号转导与基因调控实验室课题负责人;中科大医药生物技术系常务副主任;中科大生物医药工程技术研究中心主任;中国抗癌协会肿瘤生物治疗分会副主任委员;安徽省生物工程学会理事长。主持国家自然基金7项;973课题组长、骨干成员3项;国家新药创制重大专项负责人、骨干成员各1项;省部级重大、重点项目10余项。发表SCI收录研究论文40余篇;申请专利16项,获授权8项。

主要研究领域:
 1. 分子肿瘤和分子免疫学
      * 肿瘤细胞复杂信号网络异常及基因调控机制和作用
      * 炎症与肿瘤的作用与机制
 2. 生物技术及药物的研究开发
      * 生物技术药物及免疫治疗技术和产品的研发

部分发表研究论文:

  1. Jia, H., Y. Guo, X. Song, C. Shao, J. Wu, J. Ma, M. Shi, Y. Miao, R. Li, D. Wang, Z. Tian, and W. Xiao. 2016. Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-alpha/Fc fusion proteins expressed in Pichia pastoris. Microb Cell Fact 15: 209.
  2. Wang, D., J. Y. Chen, R. Li, G. L. Wu, Z. M. Sun, Z. T. Wang, Z. M. Zhai, F. Fang, Y. G. Guo, Y. J. Zhong, M. Jiang, H. Xu, M. H. Chen, G. D. Shen, J. Sun, B. L. Yan, C. D. Yu, Z. G. Tian, and W. H. Xiao. 2016. PAX5 interacts with RIP2 to promote NF-kappa B activation and drug-resistance in B-lymphoproliferative disorders. J. Cell Sci. 129: 2261-2272.
  3. Guo, Y. G., J. Wu, H. Jia, W. Chen, C. S. Shao, L. Zhao, J. J. Ma, R. Li, Y. J. Zhong, F. Fang, D. Wang, J. Sun, F. Qian, X. R. Dai, G. H. Zhang, Z. G. Tian, B. X. Li, and W. H. Xiao. 2015. Balancing the Expression and Production of a Heterodimeric Protein: Recombinant Agkisacutacin as a Novel Antithrombotic Drug Candidate. Sci Rep 5: 10.
  4. Zhong, Y. J., L. Yang, Y. G. Guo, F. Fang, D. Wang, R. Li, M. Jiang, W. Y. Kang, J. J. Ma, J. Sun, and W. H. Xiao. 2014. High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10. Microb. Cell. Fact. 13: 10.
  5. Ren, Z. J., W. Y. Kang, L. H. Wang, B. L. Sun, J. J. Ma, C. G. Zheng, J. Sun, Z. G. Tian, X. Y. Yang, and W. H. Xiao. 2014. E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-kB modulation. Mol. Cancer 13: 13.
  6. Guo, Y. G., R. Li, X. P. Song, Y. J. Zhong, C. G. Wang, H. Jia, L. D. Wu, D. Wang, F. Fang, J. Ma, W. Y. Kang, J. Sun, Z. G. Tian, and W. H. Xiao. 2014. The Expression and Characterization of Functionally Active Soluble CD83 by Pichia pastoris Using High-Density Fermentation. PLoS One 9: 8.
  7. Sun, H. Y., C. Sun, and W. H. Xiao. 2014. Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations. Cytokine 65: 33-41.
  8. Cheng, M., Y. Y. Chen, W. H. Xiao, R. Sun, and Z. G. Tian. 2013. NK cell-based immunotherapy for malignant diseases. Cell. Mol. Immunol. 10: 230-252.
  9. Sun, H. Y., C. Sun, Z. G. Tian, and W. H. Xiao. 2013. NK cells in immunotolerant organs. Cell. Mol. Immunol. 10: 202-212.
  10. Ma, Y., Q. Q. Cheng, Z. J. Ren, L. Xu, Y. Zhao, J. Sun, S. Y. Hu, and W. H. Xiao. 2012. Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate cancer cells. Cancer Lett. 317: 150-156.
  11. Fang, F., Y. Wang, R. Li, Y. Zhao, Y. Guo, M. Jiang, J. Sun, Y. Ma, Z. J. Ren, Z. G. Tian, F. Wei, D. Yang, and W. H. Xiao. 2010. Transcription Factor E2F1 Suppresses Dendritic Cell Maturation. J. Immunol. 184: 6084-6091.
  12. Ma, J. J., Z. J. Ren, Y. Ma, L. Xu, Y. Zhao, C. G. Zheng, Y. H. Fang, T. Xue, B. L. Sun, and W. H. Xiao. 2009. Targeted Knockdown of EGR-1 Inhibits IL-8 Production and IL-8-mediated Invasion of Prostate Cancer Cells through Suppressing EGR-1/NF-kappa B Synergy. J. Biol. Chem. 284: 34600-34606.
  13. Zheng, C. G., Z. J. Ren, H. T. Wang, W. C. Zhang, D. V. Kalvakolanu, Z. G. Tian, and W. H. Xiao. 2009. E2F1 Induces Tumor Cell Survival via Nuclear Factor-kappa B-Dependent Induction of EGR1 Transcription in Prostate Cancer Cells. Cancer Res. 69: 2324-2331.
  14. Xiao, W. H., D. R. Hodge, L. H. Wang, X. Y. Yang, X. H. Zhang, and W. L. Farrar. 2004. NF-kappa B activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NF kappa B regulatory site in autocrine human multiple myeloma cells. Cancer Biol. Ther. 3: 1007-1017.
  15. Xiao, W. H., L. H. Wang, X. Y. Yang, T. S. Chen, D. Hodge, P. F. Johnson, and W. Farrar. 2001. CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma) gene transcription in human monocytic cells. J. Biol. Chem. 276: 23275-23281.
  16. Xiao, W. H., S. Ramanujam, D. J. Lindner, R. D. Kudaravalli, R. Freund, and D. V. Kalvakolanu. 1998. The polyoma virus T antigen interferes with interferon-inducible gene expression. Proc. Natl. Acad. Sci. U. S. A. 95: 1085-1090.
  17. Xiao, W. H., V. Kolla, and D. V. Kalvakolanu. 1997. Interferon gamma-induced transcription of the murine ISGF3 gamma (p48) gene is mediated by novel factors. Proc. Natl. Acad. Sci. U. S. A. 94: 103-108.
  18. Xiao, W. H., D. J. Lindner, and D. V. Kalvakolanu. 1997. The interferon-inducible murine p48 (ISGF3 gamma) gene is regulated by protooncogene c-myc. Proc. Natl. Acad. Sci. U. S. A. 94: 7227-7232.