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Prof. Weihua Xiao

WEIHUA XIAO

Professor, Executive Director of Program of Biotechnology, Institute of Immunology and School of Life Science, University of Science and Technology of China; President of Society of Biotechnology of Anhui Province.

Contact Info:
    Tel: 86-551-63606429(O); 86-551-63600536(Lab);
    E-mail: xiaow@ustc.edu.cn
Mailing address:
    #443 Huangshan Road, Hefei, Anhui province China 230027
Website:
    Lab:  http://lstt.ustc.edu.cn
    GMP Lab:  http://gmp.ustc.edu.cn
    Dept. of Biotech:  http://biodept.ustc.edu.cn

Personal Profile:
Dr. Xiao received his B.S and PhD. in Medicine from Norman Bethune University, Changchun China, and M.S. in Bioinformatics from Johon Hopkins University, Maryland USA. He was a research associate at Changchun Institute of Biological Products, Changchun, China from 1985 to 1995, and a postdoctoral fellow in Cancer Canter, school of medicine, University of Maryland from 1995 to 1998, a scientist at National Cancer Institute, NIH, USA from 1998 to 2005. In the late of 2004, he became a Principle Investigator at Institute of Immunology and School of Life Science in University of Science & Technology of China, and appointed as executive director of the program of medicinal biotechnology and director of GMP Laboratory of Medicinal biotechnology. He published more than 40 research articles on peer review journals and 16 patents including 8 issued patents.

Research Interests:
Molecular Cancer Biology and Molecular Immunology
    * Signaling transduction and transcription in cancer and immune cells
    * Inflammation and Cancer Immunity
Medicinal Biotechnology
    * Biological drugs and Immune therapy technology and products development

Selected Publications:

  1. Yangyang Li, Siqi Xie, Minhua Chen, Hao Li, Yehai Wang, Yan Fan, Kang An, Yu Wu and Weihua Xiao. Development of an antibody-ligand fusion protein scFvCD16A-sc4-1BBL in Komagataella phaffii with stimulatory activity for Natural Killer cells. Microb Cell Fact. 22, 67 (2023).
  2. Fang F, Xie S, Chen M, Li Y, Yue J, Ma J, Shu X, He Y, Xiao W, Tian Z. Advances in NK cell production. Cell Mol Immunol. 2022 Apr;19(4):460-481.
  3. Chen, M.; Li, Y.; Wu, Y.; Xie, S.; Ma, J.; Yue, J.; Lv, R.; Tian, Z.; Fang, F.; Xiao, W. Anti-Tumor Activity of Expanded PBMC-Derived NK Cells by Feeder-Free Protocol in Ovarian Cancer. Cancers. 2021, 13, 5866.
  4. Huan Xu, Mingyang Shi, Changsheng Shao, Hao Li, Jing Wu, Yin Yu, Fang Fang, Yugang Guo, Weihua Xiao. Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives. Microb Cell Fact. 20, 115 (2021).
  5. Miao Y, Jiang M, Qi L, Yang, Xiao W, Fang F. BCAP Regulates Dendritic Cell Maturation Through the Dual-Regulation of NF-κB and PI3K/AKT Signaling During Infection. Front Immunol. 2020 Feb 18;11:250.
  6. Lu Qi , Qiuyan Zhang, Yuhui Miao, Wenyao Kang, Zhigang Tian, Damo Xu, Weihua Xiao, Fang Fang. Interleukin-33 Activates and Recruits Natural Killer Cells to Inhibit Pulmonary Metastatic Cancer Development. Int J Cancer. 2020 Mar 1;146(5):1421-1434
  7. Huimin Liu, Siqi Xie, Fang Fang, Dhananjaya V. Kalvakolanu and Weihua Xiao. SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response. Cell Death Dis. 11, 445 (2020).
  8. Jia, H., Y. Guo, X. Song, C. Shao, J. Wu, J. Ma, M. Shi, Y. Miao, R. Li, D. Wang, Z. Tian, and W. Xiao. 2016. Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-alpha/Fc fusion proteins expressed in Pichia pastoris. Microb Cell Fact 15: 209.
  9. Wang, D., J. Y. Chen, R. Li, G. L. Wu, Z. M. Sun, Z. T. Wang, Z. M. Zhai, F. Fang, Y. G. Guo, Y. J. Zhong, M. Jiang, H. Xu, M. H. Chen, G. D. Shen, J. Sun, B. L. Yan, C. D. Yu, Z. G. Tian, and W. H. Xiao. 2016. PAX5 interacts with RIP2 to promote NF-kappa B activation and drug-resistance in B-lymphoproliferative disorders. J. Cell Sci. 129: 2261-2272.
  10. Guo, Y. G., J. Wu, H. Jia, W. Chen, C. S. Shao, L. Zhao, J. J. Ma, R. Li, Y. J. Zhong, F. Fang, D. Wang, J. Sun, F. Qian, X. R. Dai, G. H. Zhang, Z. G. Tian, B. X. Li, and W. H. Xiao. 2015. Balancing the Expression and Production of a Heterodimeric Protein: Recombinant Agkisacutacin as a Novel Antithrombotic Drug Candidate. Sci Rep 5: 10.
  11. Zhong, Y. J., L. Yang, Y. G. Guo, F. Fang, D. Wang, R. Li, M. Jiang, W. Y. Kang, J. J. Ma, J. Sun, and W. H. Xiao. 2014. High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10. Microb. Cell. Fact. 13: 10.
  12. Ren, Z. J., W. Y. Kang, L. H. Wang, B. L. Sun, J. J. Ma, C. G. Zheng, J. Sun, Z. G. Tian, X. Y. Yang, and W. H. Xiao. 2014. E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-kB modulation. Mol. Cancer 13: 13.
  13. Guo, Y. G., R. Li, X. P. Song, Y. J. Zhong, C. G. Wang, H. Jia, L. D. Wu, D. Wang, F. Fang, J. Ma, W. Y. Kang, J. Sun, Z. G. Tian, and W. H. Xiao. 2014. The Expression and Characterization of Functionally Active Soluble CD83 by Pichia pastoris Using High-Density Fermentation. PLoS One 9: 8.
  14. Sun, H. Y., C. Sun, and W. H. Xiao. 2014. Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations. Cytokine 65: 33-41.
  15. Cheng, M., Y. Y. Chen, W. H. Xiao, R. Sun, and Z. G. Tian. 2013. NK cell-based immunotherapy for malignant diseases. Cell. Mol. Immunol. 10: 230-252.
  16. Sun, H. Y., C. Sun, Z. G. Tian, and W. H. Xiao. 2013. NK cells in immunotolerant organs. Cell. Mol. Immunol. 10: 202-212.
  17. Ma, Y., Q. Q. Cheng, Z. J. Ren, L. Xu, Y. Zhao, J. Sun, S. Y. Hu, and W. H. Xiao. 2012. Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate cancer cells. Cancer Lett. 317: 150-156.
  18. Fang, F., Y. Wang, R. Li, Y. Zhao, Y. Guo, M. Jiang, J. Sun, Y. Ma, Z. J. Ren, Z. G. Tian, F. Wei, D. Yang, and W. H. Xiao. 2010. Transcription Factor E2F1 Suppresses Dendritic Cell Maturation. J. Immunol. 184: 6084-6091.
  19. Ma, J. J., Z. J. Ren, Y. Ma, L. Xu, Y. Zhao, C. G. Zheng, Y. H. Fang, T. Xue, B. L. Sun, and W. H. Xiao. 2009. Targeted Knockdown of EGR-1 Inhibits IL-8 Production and IL-8-mediated Invasion of Prostate Cancer Cells through Suppressing EGR-1/NF-kappa B Synergy. J. Biol. Chem. 284: 34600-34606.
  20. Zheng, C. G., Z. J. Ren, H. T. Wang, W. C. Zhang, D. V. Kalvakolanu, Z. G. Tian, and W. H. Xiao. 2009. E2F1 Induces Tumor Cell Survival via Nuclear Factor-kappa B-Dependent Induction of EGR1 Transcription in Prostate Cancer Cells. Cancer Res. 69: 2324-2331.
  21. Xiao, W. H., D. R. Hodge, L. H. Wang, X. Y. Yang, X. H. Zhang, and W. L. Farrar. 2004. NF-kappa B activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NF kappa B regulatory site in autocrine human multiple myeloma cells. Cancer Biol. Ther. 3: 1007-1017.
  22. Xiao, W. H., L. H. Wang, X. Y. Yang, T. S. Chen, D. Hodge, P. F. Johnson, and W. Farrar. 2001. CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma) gene transcription in human monocytic cells. J. Biol. Chem. 276: 23275-23281.
  23. Xiao, W. H., S. Ramanujam, D. J. Lindner, R. D. Kudaravalli, R. Freund, and D. V. Kalvakolanu. 1998. The polyoma virus T antigen interferes with interferon-inducible gene expression. Proc. Natl. Acad. Sci. U. S. A. 95: 1085-1090.
  24. Xiao, W. H., V. Kolla, and D. V. Kalvakolanu. 1997. Interferon gamma-induced transcription of the murine ISGF3 gamma (p48) gene is mediated by novel factors. Proc. Natl. Acad. Sci. U. S. A. 94: 103-108.
  25. Xiao, W. H., D. J. Lindner, and D. V. Kalvakolanu. 1997. The interferon-inducible murine p48 (ISGF3 gamma) gene is regulated by protooncogene c-myc. Proc. Natl. Acad. Sci. U. S. A. 94: 7227-7232.